Clinically shown to reduce crying time by 50%.* Probiotic L. reuteri to improve the friendly bacteria in baby's digestive system.* Safe for infants. For best results, use 5 drops once daily. Shake well before use. Turn bottle to a 45° angle to slowly form a drop. Drops can be given on the breast, mixed with breast milk or formula, or by spoon.* Bottle contains a 25 day supply. Storage: Store in a cool, dry place.